See publications on pubmed and google scholar.


Tamir Bendory, Alberto Bartesaghi, Amit Singer (2020) Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities, IEEE Signal Processing Magazine 37(2), p. 58-76, url, doi:10.1109/MSP.2019.2957822

Rory Henderson, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, Elizabeth Carter, Scott C. Blanchard, R J Edwards, Kevin Wiehe, Kevin O. Saunders, Mario J. Borgnia, Alberto Bartesaghi, Walther Mothes, Barton F. Haynes, Priyamvada Acharya, S. Munir Alam (2020) Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements, Nature Communications 11(1), p. 520, url, doi:10.1038/s41467-019-14196-w


Ye Zhou, Amit Moscovich, Tamir Bendory, Alberto Bartesaghi (2019) Unsupervised particle sorting for high-resolution single-particle cryo-EM, Inverse Problems, IOP Publishing, url, doi:10.1088/1361-6420/ab5ec8


Alberto Bartesaghi, Cecilia Aguerrebere, Veronica Falconieri, Soojay Banerjee, Lesley A. Earl, Xing Zhu, Nikolaus Grigorieff, Jacqueline L.S. Milne, Guillermo Sapiro, Xiongwu Wu, Sriram Subramaniam (2018) Atomic Resolution Cryo-EM Structure of β-Galactosidase, Structure 26(6), p. 848-856.e3, pubmed, doi:10.1016/j.str.2018.04.004

Y Kang, O Kuybeda, PW de Waal, S Mukherjee, N Van Eps, P Dutka, XE Zhou, A Bartesaghi, S Erramilli, T Morizumi, X Gu, Y Yin, P Liu, Y Jiang, X Meng, G Zhao, K Melcher, OP Ernst, AA Kossiakoff, S Subramaniam, HE Xu (2018) Cryo-EM structure of human rhodopsin bound to an inhibitory G protein, Nature 558, p. 553-558, pubmed, doi:10.1038/s41586-018-0215-y

Doreen Matthies, Chanhyung Bae, Gilman ES Toombes, Tara Fox, Alberto Bartesaghi, Sriram Subramaniam, Kenton Jon Swartz (2018) Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs, eLife 7(e37558), url, doi:10.7554/eLife.37558


TW Guo, A Bartesaghi, H Yang, V Falconieri, P Rao, A Merk, ET Eng, AM Raczkowski, T Fox, LA Earl, DJ Patel, S Subramaniam (2017) Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex, Cell 171(2), p. 414-426.e12, pubmed, doi:10.1016/j.cell.2017.09.006


C Aguerrebere, M Delbracio, A Bartesaghi, G Sapiro (2016) Fundamental Limits in Multi-Image Alignment, IEEE Transactions on Signal Processing 64(21), p. 5707-5722, url, doi:10.1109/TSP.2016.2600517

S Banerjee, A Bartesaghi, A Merk, P Rao, SL Bulfer, Y Yan, N Green, B Mroczkowski, RJ Neitz, P Wipf, V Falconieri, RJ Deshaies, JLS Milne, D Huryn, M Arkin, S Subramaniam (2016) 2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition, Science 351(6275), p. 871-875, pubmed, doi:10.1126/science.aad7974

MJ Borgnia, S Banerjee, A Merk, D Matthies, A Bartesaghi, P Rao, J Pierson, LA Earl, V Falconieri, S Subramaniam, JLS Milne (2016) Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase, Molecular Pharmacology 89(6), p. 645-651, pubmed, doi:10.1124/mol.116.103382

GA Frank, S Shukla, P Rao, MJ Borgnia, A Bartesaghi, A Merk, A Mobin, L Esser, LA Earl, MM Gottesman, D Xia, SV Ambudkar, S Subramaniam (2016) Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle, Molecular Pharmacology 90(1), p. 35-41, pubmed, doi:10.1124/mol.116.104190

A Merk, A Bartesaghi, S Banerjee, V Falconieri, P Rao, MI Davis, R Pragani, MB Boxer, LA Earl, JLS Milne, S Subramaniam (2016) Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery, Cell 165(7), p. 1698-1707, pubmed, doi:10.1016/j.cell.2016.05.040

EEH Tran, KA Podolsky, A Bartesaghi, O Kuybeda, G Grandinetti, TJ Wohlbold, GS Tan, R Nachbagauer, P Palese, F Krammer, S Subramaniam (2016) Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate, mBio 7(2), p. e00257-16, pubmed, doi:10.1128/mBio.00257-16


Alberto Bartesaghi, Alan Merk, Soojay Banerjee, Doreen Matthies, Xiongwu Wu, Jacqueline L.S. Milne, Sriram Subramaniam (2015) 2.2 å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor, Science 348(6239), p. 1147-1151, pubmed, doi:10.1126/science.aab1576


A Bartesaghi, D Matthies, S Banerjee, A Merk, S Subramaniam (2014) Structure of B-galactosidase at 3.2-A resolution obtained by cryo-electron microscopy, Proceedings of the National Academy of Sciences 111(32), p. 11709-11714, pubmed, doi:10.1073/pnas.1402809111

JR Meyerson, J Kumar, S Chittori, P. Rao, J Pierson, A Bartesaghi, ML Mayer, S Subramaniam (2014) Structural mechanism of glutamate receptor activation and desensitization, Nature 514(7522), p. 328-334, pubmed, doi:10.1038/nature13603

EEH Tran, JA Simmons, A Bartesaghi, CJ Shoemaker, E Nelson, JM White, S Subramaniam (2014) Spatial Localization of the Ebola Virus Glycoprotein Mucin-Like Domain Determined by Cryo-Electron Tomography, Journal of Virology 88(18), p. 10958-10962, pubmed, doi:10.1128/JVI.00870-14

TS Yoo, BC Lowekamp, O Kuybeda, K Narayan, GA Frank, A Bartesaghi, M Borgnia, S Subramaniam, G Sapiro, MJ Ackerman (2014) Accelerating Discovery in 3D Microanalysis: Leveraging Open Source Software and Deskside High Performance Computing, Microsc. Microanal 20, url


A Bartesaghi, A Merk, MJ Borgnia, JLS Milne, S Subramaniam (2013) Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy., Nature structural & molecular biology 20(12), p. 1352-7, pubmed, doi:10.1038/nsmb.2711

AK Harris, A Bartesaghi, JLS Milne, S Subramaniam (2013) HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1., Journal of virology 87(12), p. 7191-6, pubmed, doi:10.1128/JVI.03284-12

O Kuybeda, GA Frank, A Bartesaghi, MJ Borgnia, S Subramaniam, G Sapiro (2013) A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography, Journal of Structural Biology 181(2), p. 116-127, pubmed, doi:10.1016/j.jsb.2012.10.010

JLS Milne, MJ Borgnia, A Bartesaghi, EEH Tran, LA Earl, DM Schauder, J Lengyel, J Pierson, A Patwardhan, S Subramaniam (2013) Cryo-electron microscopy - A primer for the non-microscopist, FEBS Journal 280(1), p. 28-45, pubmed, doi:10.1111/febs.12078

DM Schauder, O Kuybeda, J Zhang, K Klymko, A Bartesaghi, MJ Borgnia, ML Mayer, S Subramaniam (2013) Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain., Proceedings of the National Academy of Sciences of the United States of America 110(15), p. 5921-6, pubmed, doi:10.1073/pnas.1217549110


A Bartesaghi, F Lecumberry, G Sapiro, S Subramaniam (2012) Protein secondary structure determination by constrained single-particle cryo-electron tomography, Structure 20(12), p. 2003-2013, pubmed, doi:10.1016/j.str.2012.10.016

GA Frank, A Bartesaghi, O Kuybeda, MJ Borgnia, TA White, G Sapiro, S Subramaniam (2012) Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging, Journal of Structural Biology 178(2), p. 165-176, pubmed, doi:10.1016/j.jsb.2012.01.004

EEH Tran, MJ Borgnia, O Kuybeda, DM Schauder, A Bartesaghi, GA Frank, G Sapiro, JLS Milne, S Subramaniam (2012) Structural mechanism of trimeric HIV-1 envelope glycoprotein activation, PLoS Pathogens 8(7), p. 37, pubmed, doi:10.1371/journal.ppat.1002797


A Harris, MJ Borgnia, D Shi, A Bartesaghi, H He, R Pejchal, YK Kang, R Depetris, AJ Marozsan, RW Sanders, PJ Klasse, JLS Milne, I.A. Wilson, WC Olson, JP Moore, S Subramaniam (2011) Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures., Proceedings of the National Academy of Sciences of the United States of America 108(28), p. 11440-11445, pubmed, doi:10.1073/pnas.1101414108

JR Meyerson, TA White, D Bliss, A Moran, A Bartesaghi, MJ Borgnia, MJV de la Cruz, D Schauder, LM Hartnell, R Nandwani, M Dawood, B Kim, JH Kim, J Sununu, L Yang, S Bhatia, C Subramaniam, DE Hurt, L Gaudreault, S Subramaniam (2011) Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging, Journal of Visualized Experiments(58), pubmed, doi:10.3791/2770

TA White, A Bartesaghi, MJ Borgnia, MJV de la Cruz, R Nandwani, JA Hoxie, JW Bess, JD Lifson, JLS Milne, S Subramaniam (2011) Three-Dimensional Structures of Soluble CD4-Bound States of Trimeric Simian Immunodeficiency Virus Envelope Glycoproteins Determined by Using Cryo-Electron Tomography, Journal of Virology 85(23), p. 12114-12123, pubmed, doi:10.1128/JVI.05297-11


TA White, A Bartesaghi, MJ Borgnia, JR Meyerson, MJV De la Cruz, JW Bess, R Nandwani, JA Hoxie, JD Lifson, JLS Milne, S Subramaniam (2010) Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: Strain- dependent variation in quaternary structure, PLoS Pathogens 6(12), pubmed, doi:10.1371/journal.ppat.1001249


A Bartesaghi, S Subramaniam (2009) Membrane protein structure determination using cryo-electron tomography and 3D image averaging, Curr. Opin. Struct. Biol. 19(4), p. 402-407, pubmed, doi:10.1016/


A Bartesaghi, P Sprechmann, J Liu, G Randall, G Sapiro, S Subramaniam (2008) Classification and 3D averaging with missing wedge correction in biological electron tomography☆, Journal of Structural Biology 162(3), p. 436-450, pubmed, doi:10.1016/j.jsb.2008.02.008

J Liu, A Bartesaghi, MJ Borgnia, G Sapiro, S Subramaniam (2008) Molecular architecture of native HIV-1 gp120 trimers., Nature 455(7209), p. 109-113, pubmed, doi:10.1038/nature07159


I Aganj, A Bartesaghi, M Borgnia, HY Liao, G Sapiro, S Subramaniam (2007) Regularization for inverting the radon transform with wedge consideration, 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, p. 217-220, IEEE, url, doi:10.1109/ISBI.2007.356827

R Sougrat, A Bartesaghi, JD Lifson, AE Bennett, JW Bess, DJ Zabransky, S Subramaniam (2007) Electron tomography of the contact between T cells and SIV/HIV-1: Implications for viral entry, PLoS Pathogens 3(5), p. 0571-0581, pubmed, doi:10.1371/journal.ppat.0030063

S Subramaniam, A Bartesaghi, J Liu, AE Bennett, R Sougrat (2007) Electron tomography of viruses, Current Opinion in Structural Biology 17(5), p. 596-602, pubmed, doi:10.1016/


A Bartesaghi, M Nadar (2006) Segmentation of Anatomical Structure from DT-MRI, 3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006., p. 61-64, IEEE, url, doi:10.1109/ISBI.2006.1624852

A Mohan, A Bartesaghi, G Sapiro (2006) Constrained regularization of digital terrain elevation data, IEEE Geoscience and Remote Sensing Letters 3(1), p. 59-62, url, doi:10.1109/LGRS.2005.856702

L Yatziv, A Bartesaghi, G Sapiro (2006) O(N) implementation of the fast marching algorithm, Journal of Computational Physics 212(2), p. 393-399, url, doi:10.1016/


A Bartesaghi, G Sapiro (2005) Tracking of moving objects under severe and total occlusions, IEEE International Conference on Image Processing, p. I-301, IEEE, url, doi:10.1109/ICIP.2005.1529747

A Bartesaghi, G Sapiro, T Malzbender, D Gelb (2005) Three-dimensional shape rendering from multiple images, Graphical Models 67(4), p. 332-346, url, doi:10.1016/j.gmod.2005.02.002

A Bartesaghi, G Sapiro, S Subramaniam (2005) An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms, IEEE Transactions on Image Processing 14(9), p. 1314-1323, pubmed, doi:10.1109/TIP.2005.852467


A Bartesaghi, G Sapiro, S Lee, J Lefman, S Wahl, J Orenstein, S Subramaniam (2004) A new approach for 3D segmentation of cellular tomograms obtained using three-dimensional electron microscopy, 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano 2, p. 5-8, IEEE, url, doi:10.1109/ISBI.2004.1398460

A Bartesaghi, G Sapiro, T Malzbender, D Gelb (2004) Non-photorealistic rendering from multiple images, Proceedings - International Conference on Image Processing, ICIP 4, p. 2403-2406, url, doi:10.1109/ICIP.2004.1421585


A Bartesaghi, A Fernández, A Gómez (2001) Performance Evaluation of an Automatic Fingerprint Classification Algorithm Adapted to a Vucetich Based Classification System, p. 259-265, Springer, Berlin, Heidelberg, url

A Bartesaghi, G Sapiro (2001) A system for the generation of curves on 3D brain images, Human Brain Mapping 14(1), p. 1-15, pubmed, doi:10.1002/hbm.1037