• Nature Reviews Drug Discovery, July 2018
    • Nature Reviews Drug Discovery, July 2018
    • Nature Reviews Drug Discovery, July 2018
    •   Cryo-EM in drug discovery: achievements, limitations and prospects Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies — have raised hopes that it might soon become an important tool for drug discovery, particularly for 'intractable' targets that are still not accessible to analysis by…
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    • Nature Structural & Molecular Biology, December 2013
    • Nature Structural & Molecular Biology, December 2013
    •   Prefusion Structure of Trimeric HIV-1 Envelope Glycoprotein Determined by Cryo-Electron Microscopy HIV-1 Env transitions from a closed to an open state upon binding to its cellular receptor. Single-particle cryo-EM analysis now reveals the closed state of the HIV-1 Env trimer at ~6-Å resolution, featuring three gp41 helices at the center of the trimer depicted here by the tri-fold organization…
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  • The FEBS Journal, January 2013
    • The FEBS Journal, January 2013
    • The FEBS Journal, January 2013
    •   Cryo-Electron Microscopy – A Primer for the Non-Microscopist From molecules to viruses and cells: Bridging the gap with 3D electron microscopy FEBS Journal, 280(1), 2013.
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