• Glycoprotein Spikes on Intact HIV and SIV Viruses
    • Glycoprotein Spikes on Intact HIV and SIV Viruses
    • Glycoprotein Spikes on Intact HIV and SIV Viruses
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    •   Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure HIV and SIV contact and infect target T-cells following the binding of trimeric Env spikes displayed on the viral membrane with cellular receptors. The conformational changes in trimeric Env that are triggered by the interaction between trimeric Env and cell surface receptors…
  • Structure of Native HIV-1 gp120 Trimers
    • Structure of Native HIV-1 gp120 Trimers
    • Structure of Native HIV-1 gp120 Trimers
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    •   Molecular Architecture of Native HIV-1 gp120 Trimers We determined the structure of the native gp120 coat protein of HIV by cryo-electron tomography and molecular modelling. Comparison of gp120 structures in an unbound state, bound to a neutralizing antibody and bound to CD4 cell surface protein provides insight into the conformational changes that occur during antibody neutralization and attachment to…