Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities This issue of IEEE Signal Processing Magazine includes three feature articles covering cooperative wireless caching, atomic norm minimization for super- resolution, and single-particle cryo-electron microscopy (the latter on which this issue’s cover design is based). Signal Processing Magazine, 37(2), March 2020.
Cryo-EM in drug discovery: achievements, limitations and prospects Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies — have raised hopes that it might soon become an important tool for drug discovery, particularly for 'intractable' targets that are still not accessible to analysis by…
Prefusion Structure of Trimeric HIV-1 Envelope Glycoprotein Determined by Cryo-Electron Microscopy HIV-1 Env transitions from a closed to an open state upon binding to its cellular receptor. Single-particle cryo-EM analysis now reveals the closed state of the HIV-1 Env trimer at ~6-Å resolution, featuring three gp41 helices at the center of the trimer depicted here by the tri-fold organization…
A Collaborative Framework for 3D Alignment and Classification of Heterogeneous Subvolumes in Cryo-Electron Tomography Journal of Structural Biology, 181(2), 2013.
Cryo-Electron Microscopy – A Primer for the Non-Microscopist From molecules to viruses and cells: Bridging the gap with 3D electron microscopy FEBS Journal, 280(1), 2013.
