• Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs
  • Structure of rhodopsin bound to an inhibitory G protein
    • Structure of rhodopsin bound to an inhibitory G protein
    • Structure of rhodopsin bound to an inhibitory G protein
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    •   Cryo-EM structure of human rhodopsin bound to an inhibitory G protein For the first time, scientists have visualized the interaction between two critical components of the body’s vast cellular communication network, a discovery that could lead to more effective medications with fewer side effects for conditions ranging from migraine to cancer. The near-atomic resolution images obtained, show a G-protein coupled…
  • Cryo-EM Analysis of Human P-glycoprotein
  • Structures of Chimeric Hemagglutinin on Influenza Virus
    • Structures of Chimeric Hemagglutinin on Influenza Virus
    • Structures of Chimeric Hemagglutinin on Influenza Virus
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    •   Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate Chimeric hemagglutinin proteins are set to undergo human clinical trials as a universal influenza vaccine candidate, yet no structural information for these proteins is available. Using cryo-electron tomography, we report the first three-dimensional (3D) visualization of chimeric hemagglutinin proteins displayed on the surface of the influenza…
  • Structure of Magnesium Channel CorA
    • Structure of Magnesium Channel CorA
    • Structure of Magnesium Channel CorA
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    •   Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating Magnesium ions (Mg2+) play essential roles in all living organisms. Bacteria and other prokaryotes rely upon the Mg2+-dependent channel CorA, which is composed of five identical subunits (A-E), to obtain these ions from their surroundings. Studies of CorA showed that, in contrast to most ligand-gated ion channels,…
  • Structure of Ebola Glycoprotein Mucin-like Domain
  • Three-state Solution for Glutamate Receptor Structure
    • Three-state Solution for Glutamate Receptor Structure
    • Three-state Solution for Glutamate Receptor Structure
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    •   Structural Mechanism of Glutamate Receptor Activation and Desensitization Understanding the structural basis of the transition from closed to active and desensitized conformations is central to deciphering the function of ionotropic glutamate receptors NMDA receptors, AMPA receptors, delta receptors, and kainate receptors as mediators of excitatory synaptic transmission in the central nervous system. Ligand binding at the receptor's extracellular surface…
  • Prefusion Structure of Trimeric HIV-1
    • Prefusion Structure of Trimeric HIV-1
    • Prefusion Structure of Trimeric HIV-1
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    •   Prefusion Structure of Trimeric HIV-1 Envelope Glycoprotein Determined by Cryo-Electron Microscopy HIV-1 Env transitions from a closed to an open state upon binding to its cellular receptor. Single-particle cryo-EM analysis now reveals the closed state of the HIV-1 Env trimer at ~6-Å resolution, featuring three gp41 helices at the center of the trimer. These findings indicate that HIV-1 enters…